Open for Rare
OPEN SCIENCE TO HELP CURE RARE DISEASES
We study rare disease-causing genetic variations that target biogenesis of our cell’s multisubunit enzymes, and seek for chemical compounds able to correct these defects
Mutations that cause rare diseases generally modify amino acid residues in proteins encoded by the target genes. By characterizing defects in the function of the modified proteins, our platform directly scrutinizes early stages of disease onset, generating invaluable information for biomarker and drug discovery en route to more efficient personalized treatments.
Our previous work indicates that defects in mutated gene products often target their interaction with other proteins, creating differential set of interactions (interactomes) as compared to wildtype proteins. This website presents a repertoire of differential interactomes induced by mutations causing rare genetic diseases.
Mapping Differential Interactomes
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The Montreal Clinical Research Institute is not responsible for the content of this website.