© 2019 by Open for Rare. 110, des Pins Avenue West, Montréal.

 

Open for Rare

OPEN SCIENCE TO HELP CURE RARE DISEASES

We study rare disease-causing genetic variations that target biogenesis of our cell’s multisubunit enzymes, and seek for chemical compounds able to correct these defects

 
IRCM affiliated to UdeM Logo
Regroupement québécois des maladies orphelines – RQMO
Leukodystrophy Foundation Logo
Atomwise Logo
The Montreal Neurological Institute and Hospital — The Neuro Logo
Orphanet Journal of Rare Diseases Logo

Organizations supporting our research or infrastructure projects

Génome Québec Logo
IVADO Logo

Mutations that cause rare diseases generally modify amino acid residues in proteins encoded by the target genes. By characterizing defects in the function of the modified proteins, our platform directly scrutinizes early stages of disease onset, generating invaluable information for biomarker and drug discovery en route to more efficient personalized treatments.

Our previous work indicates that defects in mutated gene products often target their interaction with other proteins, creating differential set of interactions (interactomes) as compared to wildtype proteins. This website presents a repertoire of differential interactomes induced by mutations causing rare genetic diseases.

OUR PLATFORM

 
 

Mapping Differential Interactomes

 

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